Chromatography Worksheet
Our next will involve a technique called paper chromatography.
Below are some images of the type of activity that we will
be doing. (scroll down)
The first image is something like the results we hope to get.
Then there is a drawing of the different types of pigments found in chloroplasts.







PAPER CHROMATOGRAPHY![]()

Chromatography is a method of separation of substances based on their different
mobility in a given stationary support. If you have a mixture of substances,
chromatography can allow you to separate them. For example, inks are usually
formed by a mixture of dyes, with the chromatography you can separate them and
then analyze and identify them. Chromatography is also used to obtain large
quantities of a pure substance. There are many methods of chromatography. Among
them there is paper chromatography, the thin layer chromatography (TLC), gas
chromatography, the liquid phase chromatography, the column chromatography.
Usually the mixture of substances to be separated is inserted in a solvent. The
type of solvent and of stationary medium can be chosen in a wide range of
possibilities. Usually, this choice is made according to the molecules to be
separated. According to the situation, one can exploit the molecules different
size, chemical affinity toward the support, the amount of ionization, pH,
solubility in water, etc. This experiment is for home or school so we use
solvents and supports that are easy to find. Test tubes are often used to
contain the solvent vapors, keeping the paper from drying and not overexposing
the experimenter. Later on we will give you some experiments for paper and thin
layer chromatography.
Also calculate the value of Rf of each band isolated (with reference
to the pencil line, Rf = distance moved by the solute / distance
moved by the solvent).
In these tests, the mixture to be examined has to be in high concentration. You
can prepare the mixture according to the preceding experiment. Cut a paper
filter stripe narrow enough so that it can be inserted in a test tube without
touching the walls (wider at the bottom), as shown in the figure 20. With a
pencil trace a horizontal line at 25 mm, (1 inch) from the bottom of the
stripe. Place a little drop of mixture on this line and let it dry. Place
another drop on the previous drop and let it dry. Repeat this operation to
obtain a small, very concentrated spot. With a pin, fix the stripe to the
bottom of the tube plug. Pour several cc of solvent in a test tube. There needs
to be enough so the solvent is about half way between the bottom of the paper
and the 25mm (1 inch) mark on the paper.
Insert the stripe in the tube. The smaller part of the stripe has to plunge into
the solvent without touching the bottom of the tube. The pencil line and the
spot have to be at about one cm above the surface of the solvent. For capillary
action, the solvent will be absorbed by the fibers of the paper and, when it
reaches the spot, it will start to carry the substances present in the mixture.
According to their characteristics, these substances will travel faster or
slower among the fibers of cellulose and the faster one will pull a head of the
slower and show as separate bands on the paper. Remove the stripe before the
solvent reaches the end.
With a pencil, immediately mark the position attained by the solvent and let
the stripe dry
